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Maldonado EN, Lemasters JJ

This can be especially problematic in applications where maintaining drug potency and precise delivery timing is crucial, such as cancer therapy or treating infectious diseases

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doi: 10.1056/NEJMoa2032183.

Given that this condition predominantly affects children, dedicated pediatric registries and long-term studies are essential to address the paucity of data on developmental safety, effects on linear growth and pubertal progression, and long-term cardiometabolic outcomes

Moreover, the population eligible for GLP-1 AOMs is substantially larger than the populations diagnosed with established cardiovascular disease + obesity/overweight, MASH, or OSA