FDA Safety Warnings or Clinical Trial Findings on Tirzepatide As of 2024, the FDA has not issued a black box warning specific to Zepbound, but it shares the same class-wide warning found on other GLP-1 drugs like Wegovy and Ozempic: a potential link to thyroid C-cell tumors, including medullary thyroid carcinoma (MTC)
Emerging research suggests that specific gut bacteria strains can enhance the bodys natural production of glucagon-like peptide-1 (GLP-1), an important digestive hormone
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Y., Tanimura, Y., Vage, P
Paradoxically, it also stimulates ghrelin, the hunger hormone, which can significantly increase appetite