Inhibition of SGLT-1 in the small intestine causes more glucose transport to the distal intestine and colon, resulting in greater fermentation of glucose to SCFAs by luminal bacteria and increased sustained release of GLP-1 in the distal intestine [174] (Fig
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Hypoglycaemia is particularly hazardous because of the potential to confuse the symptoms of hypoglycaemia with alcohol intoxication
hrs.2025.107770 Chen SD, Chuang YC, Lin TK, Yang JL (2023) Alternative role of glucagon-like Peptide-1 receptor agonists in neurodegenerative diseases
With clinically meaningful weight loss and cardiovascular outcomes in patients with type 2 diabetes, GLP-1RAs were further assessed in patients with overweight or obesity without type 2 diabetes in the 2021 STEP-1 trial and 2022 SURMOUNT-1 trial
This becomes particularly important since inflammation in people with obesity may reduce blood-brain barrier integrity 28
