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Last updated: March 22, 2026 Introduction to Leptin and Leptin resistance-NOTE: we now have Semaglutide and Tirzepatide

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Its results are in line with observations from clinical trials, and many doctors had suspected that tirzepatide might be more potent after seeing the results in their diabetes patients

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After taking patients' other risk factors for the condition into account, such as high blood pressure and obstructive sleep apnea, use of semaglutide was associated with a more than four times higher risk of NAION in those receiving it for diabetes and a more than seven times higher risk in patients taking it for obesity

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In regulatory speak, this means: significant safety concerns. Compounding pharmacies can no longer legally produce it for human use

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