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Additionally, it links to the cAMP/PKA and MAPK/ERK pathways, mediating activities in a Gi-dependent manner [134]

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Cited studies PMID 40277822 "Benchmark for Setting ACTH Cell Dosage in Clinical Regenerative Medicine for Post-Operative Hypopituitarism" (Journal of Clinical Endocrinology & Metabolism, 2025)

Treatment depends on the underlying cause and may include surgery for pituitary or adrenal tumours, specific medications for Cushing's syndrome, or glucocorticoid replacement therapy for adrenal insufficiency

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A vitamin B12 deficiency is seen in those who have pernicious anemia