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Moreover, manganese dioxide nanosheets loaded with Zebularine and surface-modified with hyaluronic acid to construct the nanoparticle Zeb@MH-NS can promote the accumulation of dsDNA in the cytoplasm upon reaching the tumor site, enhance the activation of the cGAS-STING signaling pathway, increase the production of type I interferons and the secretion of pro-inflammatory cytokines, and boost the maturation of DCs, the infiltration of CTLs, and the recruitment of NKs at the tumor site (231)

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Concisely, CARN status was speculated to affect MTX clearance, volume of distribution, and transporter interactions

Others suggest additional benefits such as antimicrobial and antioxidant activities, enhanced immunity, and reduced inflammation

Tang-Christensen, M., Vrang, N