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studies show that even high oral doses may not significantly raise systemic levels in a robust way

[1] [3] Taking two doses too close together increases the risk of gastrointestinal side effects such as nausea, vomiting, and diarrhoea

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Mouse spleen was carefully milled and filtered through 70 m mesh to form single-cell suspension in cold PBS

The results of this metanalysis are in line with a previous one, thus confirming that therapeutic intensification with GLP-1RA is an effective and safe approach, especially using long-acting GLP-1RAs, mostly weekly than daily administered ones (69)

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