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What Clinical Evidence Shows About GLP-1 Monotherapy Semaglutide (the active ingredient in Wegovy) demonstrated consistent weight loss in the STEP clinical trial series, with participants losing 1522% of their starting body weight over 68 weeks at standard doses

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Semaglutide is generally used for long-term weight loss, while phentermine is designed for short-term use

Sources Dietary Recommendations for the Management of Gastrointestinal Symptoms in Patients Treated with GLP-1 Receptor Agonist (PMC) Application of nutrition interventions with GLP-1 based therapies: a narrative review (PMC) Endocrine Society: Consuming more protein may protect patients taking anti-obesity drug from muscle loss (ENDO 2025) Clinical Recommendations to Manage Gastrointestinal Adverse Events in Patients Treated with GLP-1 Receptor Agonists (PMC) MedlinePlus: Fiber MedlinePlus: High-fiber foods Mayo Clinic Health System: Assessing protein needs Mayo Clinic: High-protein snacks Therapeutic Benefits and Dietary Restrictions of Fiber Intake (PMC)

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