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Elimination occurs primarily through renal clearance, with a plasma half-life of approximately 2-4 hours in rodent models

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The substantial weight loss achieved with GLP-1 receptor agonists and dual GIP/GLP-1 agonistsapproximately 15% with semaglutide 2.4 mg (Wegovy) and up to 21% with higher doses of tirzepatide (Zepbound) in clinical trialsoccurs primarily through appetite suppression and reduced caloric intake rather than increased metabolic rate

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10.1016/j.foodres.2022.111540 91 ShenF.SongZ.XieP.LiL.WangB.PengD.et al (2021)

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