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Clinically, elevated levels of endogenous GLP-1 have been observed in patients with sepsis (6.35-fold increase), end-stage renal disease (4.46-fold), and burns (2.96-fold), indicating a common physiological response to critical illness ( Despite these observations, exogenous GLP-1RAs appear to exert beneficial effects

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It is often the one that makes you think, I cannot keep doing this feeling. That is the point where many people start looking for a clinician who can manage the physiology, not just tell them withdrawal will pass

Results from EXAMINE, SAVOR-TIMI53, and TECOS also shed some light on HF