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Hesperidin (Matias et al., 2017), rutin (El-Sayed el et al., 2008), and rhamno (Omar et al., 2017) can reduce the amount of free Ca 2+ located between brain cells when fighting against neurogenic excitotoxicity and can attenuate the decrease of the mitochondrial membrane potential and increase caspase-3 activity (Lutz et al., 2015)
A deep understanding of these metabolic and inflammatory disruptions is therefore essential for developing novel therapeutic strategies, including metabolic and nutritional interventions, aimed at mitigating the health risks of excessive alcohol consumption
Front Med (Lausanne) (2022) 9:1018298