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An increase in GSSG is consistent with the role of GSH as a scavenger of free radicals and a cofactor for various antioxidant enzymes, including GPx, GST, and glutaredoxins [18]

Some research suggests that ALA may also support intracellular glutathione levels through various mechanisms

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Lipoic acid might be able to increase glutathione synthesis in aged rats by up-regulating the expression of -glutamylcysteine ligase (-GCL), the rate-limiting enzyme in glutathione synthesis (31), and by increasing cellular uptake of cysteine, an amino acid required for glutathione synthesis (32)

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We note that the changes in geometric mean costs for these APCs are associated with the APC recalibrations so that the services with clinical cost patterns that are more similar to each other are assigned to the same APC