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ElSayed NA, Aleppo G, Aroda VR, Bannuru RR, Brown FM, Bruemmer D, Collins BS, Das SR, Hilliard ME, Isaacs D, et al

While previous generations of treatments focused on one or two hormonal pathways, Retatrutide targets three distinct receptors simultaneously: GLP-1 (Glucagon-like Peptide-1): Mimics the hormone that slows gastric emptying and signals satiety to the brain to reduce food intake

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In turn, GHRH stimulates the pituitary gland to produce more growth hormone

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The persistently elevated risk amongst these trial populations demonstrates the limitations of current management strategies and highlights the need for therapies that address the link between metabolic disease and direct cardiovascular pathology