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According to the prescribing information: "In rodents, semaglutide causes dose-dependent and treatment-duration-dependent thyroid C-cell tumors at clinically relevant exposures

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Milatovic D, Zaja-Milatovic S, Breyer RM et al (2017) Neuroinflammation and oxidative injury in developmental neurotoxicity

These individuals often report that recovery takes longer than it used to, or that recurring pain limits their activity