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While intensive chemotherapy and allogeneic hematopoietic stem cell (HSC) transplantation remain the front-line treatment option for most persons, recent US Food and Drug Administration (FDA)-approved targeted therapeutics are increasingly used to treat persons with specific genetic aberrations, such as IDH1 or FLT3 internal tandem duplication (ITD) mutations

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Ser/gly high GBM cells present increased synthesis of ser/gly-derived nucleotides and antioxidants Next, we aimed to investigate the significance of the detected PSPH amplifications (PSPH amp ) or mutations (PSPH V116I ) in patients with GBM in the pathogenesis of GBM

This protein, also present in Lb

Data availability The protein structure from accession codes 1e17 (FOXO4 FHD) was obtained from the PDB at All other data are available from the corresponding author upon reasonable request