On average, participants discontinuing liraglutide regained 2.2 kg, whereas those who had received semaglutide or tirzepatide regained almost 10 kg
Mujdat Zeybel, MD, NIHR Nottingham Biomedical Research Centre This study demonstrated CMCS supplementation significantly decreased liver fat, improved liver function, and decreased liver inflammation in NAFLD patients, suggesting CMCS may be an effective therapeutic strategy for NAFLD, No drugs have been approved to treat NAFLD, and effective treatment options with long-term safety are urgently required. The combined metabolic cofactor supplementation (CMCS) regimen developed by the Nottingham group and used in this trial consists of: 1g nicotinamide riboside (NR), which raises mitochondrial NAD+ levels, and boosts fat metabolism 3.73g L-carnitine tartrate, which promotes transport of fat into the mitochondria 12.35g L-serine, which increases glutathione synthesis 2.55g N acetyl-L-cysteine (NAC), which also promotes glutathione production and reduces oxidative stress A total of 31 patients with MRI-confirmed non-alcoholic steatosis were randomized to either placebo (N=11) or the CMCS combination (N= 20)
N Engl J Med 385:22522263
Our clinical team believes this could have profound implications for mitigating certain side effects that are sometimes tied to those initial concentration spikes
In terms of side effects and tolerability, the advantage goes to Ipamorelin
The people who tend to benefit most include: Adults with diagnosed or suspected vitamin B12 deficiency Those following restrictive diets (vegan, vegetarian) that limit B12 food sources People with gastrointestinal conditions that affect nutrient absorption Adults over 60 who are at higher risk for marginal B12 status Individuals actively working on weight loss alongside diet and exercise Health-conscious professionals who want metabolic support during busy seasons If youre unsure whether youre a good fit, the best first step is a conversation with a qualified provider
