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When to reassess If GI symptoms worsen instead of improving over the first 2-3 weeks of a step, if you cannot keep food down, or if you have severe persistent abdominal pain (especially with back radiation), pause and consult a qualified clinician

Autosomal recessive spinocerebellar ataxia 18 caused by homozygous exon 14 duplication in GRID2 and review of the literature

Treatment with a GLP-1R agonist resulted in a greater weight loss than control treatment did

Tirzepatide appears to have a peculiar impact on atherogenic dyslipidemia compared to GLP-1R monoagonists, with a preferential benefit on triglyceride levels [78, 79]

Suggested Dosage: For best results, take 1/4 teaspoon (500mg) daily with or without food

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