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Body mass data were analyzed separately for young and aged individuals due to the known differences in body mass between these groups, using two-way ANOVA with group as a between-subjects factor and time (day) as a within-subjects factor

Mechanics directs healing

Exercise: Regular physical activity boosts circulation and antioxidant defences

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Hierarchy of Evidence: Level A (Human meta-analyses and systematic reviews of CNS drug delivery)

Material and methods The key terms: rheumatoid arthritis, osteoarthritis, matrix metalloproteinases, and tissue inhibitors of metalloproteinases were searched in MEDLINE, ClinicalTrials.gov, and ScienceDirect