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When NNMT depletes SAM in adipocytes, epigenetic regulation is disrupted potentially locking in gene expression patterns that favor energy storage over expenditure

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Adipose tissue (AT) iron overload is also closely related to macrophages, mainly reflected in the important role of macrophages in controlling iron metabolism (62)

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Schumer has gone on record to say that "Mounjaro's been great" (per Entertainment Weekly)