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Glossary 2-AG 2-arachidonoylglycerol 5-HT1A 5-hydroxytryptamine receptor 1A (serotonin receptor 1A) AEA anandamide BBB bloodbrain barrier BDNF brain-derived neurotrophic factor BrdU bromodeoxyuridine CB1R cannabinoid receptor 1 CB2R cannabinoid receptor 2 CBD cannabidiol CBP cannabis-based products CNS central nervous system COX-2 cyclooxygenase-2 DCX doublecortin ECS endocannabinoid system FAAH fatty acid amide hydrolase GFAP glial fibrillary acidic protein GSH/GSSG reduced glutathione/oxidized glutathione ratio GSK-3 glycogen synthase kinase 3 beta IFG inflammaging IGF-2 insulin-like growth factor 2 IL-1 interleukin-1 IL-6 interleukin-6 LPS lipopolysaccharide MDMA 3,4-methylenedioxymethamphetamine MWT Morris water maze (test) NF-B nuclear factor kappa-light-chain-enhancer of activated B cells NO nitric oxide NOR novel object recognition (test) Ph

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doi: 10.1016/j.aju.2017.11.013 103 NazifMSRehmanZUKhanHKhanFAHussainTAhmadAet al

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A small pale dot could be sun damage, a nutrient imbalance, or a skin disorder