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Under this hypoxic and high-fat dietary environment, adipose tissue exhibits significant immune cell infiltration (macrophages, T cells) accompanied by characteristic phenotypic shifts ( Local hypoxia during adipocyte hypertrophy also induces endoplasmic reticulum stress (ERS) ( 4.3.2 Cytokine-mediated ROS generation and OS Inflammatory cytokines promote ROS production through multiple pathways ( ROS activate the NLRP3 inflammasome (37)

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The peptide appears to enhance mucosal blood flow and promote angiogenesis within the gastric mucosa, which contributes to its protective and healing properties

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