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doi: 10.1093/brain/awv222 132 CohenTJGuoJLHurtadoDEKwongLKMillsIPTrojanowskiJQet al

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Within the mitochondria itaconate inhibits the succinate dehydrogenase (SDH) complex which results in reduced flow of carbons through the TCA cycle as well as inhibition of oxidative phosphorylation since TCA cycle SDH is also complex II of the electron transport chain

The most common side effect of isotretinoin is extreme dryness, particularly of the lips

But one should be careful about aspects like sterility and hygiene, and the expertise of the person administering the treatment

Hair follicles undergo continuous cycles of growth (anagen), regression (catagen), and rest (telogen), with disruptions in this cycle leading to hair loss and thinning