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Based on the efficacy and safety records in T2DM, attention has been given to the repurposing of metformin as part of adjunct therapy for the treatment of cancer, age-related diseases, inflammatory diseases and COVID-19

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The expression of genes involved in the stress response (down-regulation of heat shock protein 70, hsp70 ), antioxidant defence (down-regulation of sod1, accompanied by up-regulation of sod2 ), and DNA repair (up-regulation of 8-oxoguanine DNA glycosylase) was significantly perturbed

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Pharmacokinetic and clinical studies with Levocarnitine have shown that administration of levocarnitine to ESRD patients on hemodialysis results in increased plasma levocarnitine concentrations