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doi: 10.1136/gutjnl-2024-334023, 47

NAION 1.32-1.50 -Simonsen et al., 2025 Diabetes, Obesity and Metabolism 44,517 16,860 semaglutide pooled HR 2.81 95% CI 1.67-4.75 10,000 +1.41 NAION HR 2.17 7.25 semaglutide NAION 2 10,000 1 NAION NAION semaglutide NAION 50 disc at risk semaglutide Ozempic Wegovy Rybelsus NAION NAION NAION EMA MHRA NAION semaglutide NAION EMA MHRA 1 NAION Semaglutide Cai 2025 semaglutide semaglutide Ozempic Wegovy Rybelsus NAION EMA2025 6 MHRA2026 2 NAION semaglutide semaglutide NAION 2 10,000 1 NAION NAION NAION semaglutide GLP-1 EMA semaglutide GLP-1 dulaglutideliraglutide NAION TirzepatideGLP-1/GIP NAION NAION NAION MHRA

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Research shows that stopping semaglutide typically leads to weight rebound because the medication's effect on hunger hormones and blood sugar regulation disappears within weeks

302(3): 8818 Perry T, Lahiri DK, Sambamurti K, et al