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Lots of people find it difficult to maintain their weight loss after medication and its common for people to regain two-thirds of their weight after 1 year of stopping Wegovy

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Lower exposure usually means fewer GI symptoms in the short term

Dieting didnt help, and I was frustrated

Preclinical research has shown that ghrelin modulates dopamine transmission in the mesocorticolimbic pathway and increases instrumental responses of (male) mice to work for food rewards 3639

So far the research is reassuring, however these are all rare, so its unlikely we will know if there is any significant increase for some years to come