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Metabolic improvements: Blood pressure, waist circumference, lipid profiles, and HbA1c all improved alongside weight reduction

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338 , 344 , 345 , 346 The likelihood of having or experiencing a known risk factor such as low levels of education, cardiovascular disease, or negative health behaviors varies by gender

While a two-year clinical trial using 300 mg per day did not show major changes in nerve function, shorter studies lasting 3 to 12 weeks found that higher doses, up to 600 mg daily, improved symptoms in people with diabetic neuropathy