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Lipoxin A4 is a potent anti-inflammatory lipid mediator that acts as an inflammatory shutdown signal to inhibit inflammatory processes

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2) Nitric oxide (NO) generated by nitric oxide synthase (NOS) disrupts IL-2 signaling via inhibition of JAK-STAT, ERK, and AKT phosphorylation, destabilizing IL-2 and inducing T-cell apoptosis (188191)