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Thereby, it is possible that this consistent BPC 157 beneficial effect on rat's pathology underlies the sudden onset of encephalopathy with paracetamol overdose as well as paracetamol overdose as the leading cause of acute liver failure in patients (3)

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In a controlled, open trial with psoriasis patients, secukinumab did not cause liver enzyme elevations, while methotrexate led to a threefold increase in liver enzymes in 4 of 64 patients, necessitating withdrawal (Gisondi et al