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For general supplementation, the differences between these forms are unlikely to be clinically meaningful for most people

Lack of vitamin B12 may cause anemia (condition in which the red blood cells do not bring enough oxygen to the organs) and permanent damage to the nerves

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May Support Energy Pathways Lipotropic B12 injections may support energy-related nutrient pathways because vitamin B12 is involved in red blood cell formation, nervous system function, and DNA synthesis

Here are some of the groups who may be more at risk for a B12 deficiency (NIH, 2020): Those with atrophic gastritis: Between 10 and 30% of older adults are afflicted with atrophic gastritis, which results in decreased absorption of foods containing B12

The details about the advantages and disadvantages of each route are present in Supplementary 4