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Exenatide treatment caused a further drop in the fasting BGL in all four meal schedule conditions

However, starting with an SGLT2 inhibitor or a GLP-1 RA in an individual who is intolerant to metformin (primarily diarrhea) is a good choice, and even in the future we may see large diabetes organizations recommending these two classes as first line therapy once they get less expensive.

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When prescribing other GLP-1 drugs off-label for weight loss, such as Ozempic or Mounjaro , health providers will typically follow these same guidelines

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