The metabolic action of GLP-1GIPlanifibranor is blunted in mice with genetic or pharmacological inhibition of GLP-1R, GIPR or PPAR and is absent in DIO double incretin receptor-knockout mice, collectively suggesting that GLP-1GIPlanifibranor has substantial therapeutic value in the treatment of obesity and diabetes
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* Correspondence: Lorenzo Drago, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
These medicines mimic a natural gut hormone, glucagon-like peptide-1, that is released after eating
Patients who have undergone treatment with Ozempic frequently report significant weight loss, often reflected in their reduced Body Mass Index (BMI)
Int J Nutr Res 47(4):349401 Khairy E, Attia M (2019) Protective effects of vitamin D on neurophysiologic alterations in brain aging: role of brain-derived neurotrophic factor (BDNF)