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That means no increase in IGF-1 production, no effect on blood glucose, no insulin resistance, no water retention, and no risk of the organ growth associated with full HGH therapy

The latter supports muscle preservation, provides necessary micronutrients, and tends to produce fewer GI complaints alongside the medication

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Where semaglutide might take 12-14 weeks to reach peak appetite suppression, retatrutide achieves clinically significant appetite changes by week 8 at therapeutic doses, and continues deepening those effects well beyond the point where semaglutide typically plateaus