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60-66 In people with early T2DM treated only with diet and exercise (SURPASS-1), tirzepatide 5 to 15 mg improved the HbA1c by 1.87% to 2.07% compared to 0.04% increase at the placebo group

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Contraindicated in patients with certain types of anemia (such as folate-deficiency anemia) where B12 supplementation may not be appropriate

Effect of glucagon-like peptide-1 receptor agonists on body weight in adults with obesity without diabetes mellitus a systematic review and meta-analysis of randomized control trials

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