Vesicular glutamate transporters have a much lower affinity for glutamate 0.5-3.5 mM than plasma membrane transporters GLT1/EAAT2, whose Km is 4-40 M (25, 26)
It includes the active form, dose, excipients, delivery system, manufacturing process, packaging and storage conditions
When it binds to copper ions, it forms the GHK-Cu complex, which plays a role in wound healing, collagen synthesis, and skin repair
In pulmonary fibrosis studies using bleomycin to induce lung injury in mice, GHK-Cu doses of 0.0026 to 0.26 mg/mL/day administered every other day reduced inflammatory cell infiltration, decreased interstitial thickness (the scarring that stiffens lung tissue), and lowered TNF-alpha and IL-6 expression
Arch Dis Child Fetal Neonatal Ed 2016
Proc Natl Acad Sci U S A