Some endogenous neuropeptides do cross via saturable transport systems, and there is speculation that DSIP may do so, but this has not been rigorously demonstrated for exogenously administered peripheral DSIP in humans
A few cross the blood-brain barrier with remarkable efficiency, delivering their signals directly to injured tissue
Features of CKD include progressive retention of nitrogenous waste products in the blood (uremia), electrolyte imbalance, metabolic acidosis, and anemia (Duranton 2012)
Choi SI, Shin YC, Lee JS, Yoon YC, Kim JM, Sung MK
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