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The study's primary endpoint was change in the cerebral glucose metabolic rate in the cortical regions of the brain (hippocampus, medial temporal lobe and posterior cingulate), which was not met

GLP-1 receptor agonists are associated with a minimal risk of hypoglycaemia because of the glucose dependency of the islet effects [32]

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Studies in the New England Journal of Medicine show patients on semaglutide lose 15-22% of body weight over 68 weeks, with the majority coming from fat mass rather than muscle

Qsymia or Contrave are your oral options until oral GLP-1 formulations for weight loss become widely available