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Light, oxygen, and moisture can impact small-molecule stability

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Second, mechanistic convergence in separate experiments is not the same as demonstrated synergy in a shared solution and a shared organism combining pro-angiogenic agents does not reliably multiply their effect, and uncontrolled angiogenesis is not an unambiguously good thing (the same vessel-forming signals that aid healing are, in other contexts, exactly what tumors exploit, which is why unsupervised pro-angiogenic stimulation is not casually assumed to be safe)

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