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The diffraction images were deposited to Integrated Resource for Reproducibility in Macromolecular Crystallography 88 ( and can be accessed via PDB 8AGQ

313610) in blocking solution for 45 min at room temperature

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While our formulation is expected to remain stable under acidic conditions and release its payload upon encountering neutral to slightly alkaline environments, the possibility of delayed or incomplete release in subsets of patients should be acknowledged

The overall structure of the GLP-1R ECD is essentially unchanged compared to the peptide-bound structures (pdb codes: 3IOL and 3C5T), except for changes of certain sidechain conformations

Biol Psychiatry 71 : 419426