Oxidative stress means an excess of reactive molecules that can damage cells over time
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showed that combination of a single transcription factor FOXA1, FOXA2, or FOXA3 with six compound cocktails, including CHIR, RepSox, valproic acid (VPA), Parnate, TTNPB, Dznep (termed CRVPTD), directly induced MEFs into iHeps ( Later studies developed protocols independent of ectopic expression for direct reprogramming
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Test results showed that the oral administration of PNE mediated a decrease in the abundance of Streptococcus intestinalis and an increase in the transgenic metabolite l-arginine, which further inhibited osteoblasts and enhanced osteoclasts through the gutbone axis, exerting a significant anti-osteoporotic effect
