XERF is a non-surgical radiofrequency skin tightening treatment that uses precisely controlled RF energy to penetrate the deeper layers of the skin
(21) In the context of significant weight loss, reduced skeletal loading may lead to an imbalance favoring osteoclastic activity and bone resorption, which could explain the decreased BMD observed in semaglutide-treated patients
^Based on a 6-month clinical trial (n=180) of individuals who were enrolled between FebruaryApril 2024, with overweight or obesity taking semaglutide or tirzepatide for weight loss and related outcomes through the WW Clinic Program and participating in the GLP-1 companion nutrition program
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Preclinical studies suggest the presence of these receptors in bone tissue and cells involved in bone remodeling, though this remains an area of ongoing investigation in humans