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Chronic GCGR activation should increase plasma glucose levels and insulin levels would then need to rise to promote normoglycaemia during tri-agonist treatment, but this is not the case
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Participants in this study were at least 66 years old and had type 2 diabetes
When 1 M exendin 2029 was applied, no significant effect was found, in contrast to the 92% inhibition elicited by 1 M BCTC (Supplementary Fig
its absence is informative but not disqualifying, especially when mechanistic and physiological evidence is otherwise robust (Nelson et al., 2015)
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