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Primary endpoints Energy expenditure and RER under indirect calorimetry, fat mass and adipocyte size, liver triglyceride content and histology, plasma lipids, and muscle performance form a coherent endpoint suite tied to ERR biology

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Biomarker Framework: When and Why B12 Supplementation Matters Before starting or adjusting B12 with semaglutide, clinical biomarkers provide objective context

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Le decisioni regolatorie del 2025-2026, culminate con lapprovazione europea di semaglutide/Kayshild per la MASH, vanno oltre questo inquadramento: un aggiornamento delle linee guida quindi atteso