Liraglutide Liraglutide, trade name Victoza, was developed by Novo Nordisk
The pathophysiology is unclear, but risk factors are thought to be the same as the type 1 diabetic patients who rapidly improved A1c in the Diabetes Control and Complications Trial: long duration of diabetes mellitus, long duration of poor glycemic control, worse baseline level of DR prior to treatment and magnitude of reduction in A1c after treatment
These molecules are more resistant to degradation by DPP-4, which results in a prolonged half-life in comparison with endogenous GLP-1
Recently, a class of medications called GLP-1 inhibitors, primarily known for their role in weight management and diabetes, has sparked interest in the mental health community
For further details on proglucagon processing see the reviews by Holst (51) and Muller et al (78)
The FDA signaled new limits on non-approved compounded GLP-1 APIs being mass-marketed, and it explicitly called out Hims