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However, there appeared to be no additional glucose-lowering effect with the addition of fenofibrate to metformin therapy in humans [24, 25]

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Potent antioxidant function at the expense of central carbon metabolism The dependency of NRF2-addicted cancer cells on exogenous glutamine is attributable to the elevated consumption and excretion of glutamate as a result of two major transcriptional outputs of NRF2 (Fig