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The hyperglycemia-related increased proximal tubular sodium reabsorption results in lower sodium levels at the level of the macula densa increasing GFR via inhibiting TGF, further augmenting the amount of filtered and reabsorbed sodium with increased ATP demands

doi: 10.1001/jamainternmed.2024.4369 14 TangHLuYDonahooWTShaoHShiLFonsecaVAet al

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National Institute of Ageing

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After reviewing the research results, the researchers concluded that doses up to 2000 mg per day are safe for long-term use and are an effective dose for most forms of L-carnitine