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Intriguingly, genetic variations with reduced IIS due to SNPs of interacting components of the IIS cascades ( GH1, IGF1, IGF1R, IRS1, FoxO1A, FoxO3A ) and have been associated with increased longevity [30, 31]
Source URMC Health Matters
Proximity ligation assay (PLA) for Cntfr and Syt1 Labelling of Cntfr was performed as described above also including mouse anti-Syt1 luminal antibodies (1:150 dilution, Synaptic Systems, cat
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