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Recently, a high-resolution crystal structure of phosphinic pseudopeptide inhibitor 45 (DG046) in the closed-conformation of ERAP1 was disclosed (Giastas et al., 2019b) and a mechanism for antigen peptide selection by ERAP1 presented (Giastas et al., 2019a)

TANs usually lack expression of tissue inhibitors of metalloproteinases (TIMP1), rendering them more angiogenic than cells that are capable of producing TIMP1/MMP9 complexes [268]

What it does is grab G-actin monomers before they polymerize prematurely, then release them at the leading edge of migrating cells in a controlled way

F., Bergman, P., Dubnov-Raz, G., Esposito, S., Ganmaa, D., Ginde, A

68 , 631635 (2013) Schneider, T

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