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Semaglutide GLP-1 is extremely helpful in promoting weight loss, with patients frequently shedding 10% or more of their starting body weight

In the trials, individuals with diabetes lost less weight with these medications than those without diabetes

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doi: 10.1016/j.molmed.2013.03.005 4 YolcuESAshSKaminitzASagivYAskenasyNYarkoniS

Another contraindication is the use of GLP-1RA in patients with a history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2 (MEN2 (33, 34, 36)

(146) observed significant blood-to-brain influx for non-acylated GLP-1 mimetics like exendin-4 and lixisenatide, whereas acylated GLP-1 analogues such as liraglutide and semaglutide showed minimal blood-brain barrier penetration in mice