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observed that reducing secondary BAs such as DCA and LCA can regulate cholesterol metabolism by inhibiting the FXR-SHP pathway and reducing the expression of SREBP1c through the FXR-PXR pathway (127)

However, these mRNA vaccines, which have been developed and approved within a few months, signify a breakthrough in the field of gene therapy, which has battled to achieve ordinary acknowledgement due to a large number of sceptical and conservative scientists and other claimed safety and translational concerns

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