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Opioid Analgesic Risk Evaluation and Mitigation Strategy (REMS): Healthcare providers are strongly encouraged to complete a REMS compliant education program and to counsel patients and caregivers on serious risks, safe use, and the importance of reading the Medication Guide with each prescription [see WARNINGS]

Consider increasing the sample volume

Behavioral assessments showed treated animals became notably more active and responsive to environmental stimuli, exhibiting exploratory behaviors typically absent in aged subjects

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This helps reduce the toxic burden on the liver, allowing it to function more effectively

doi: 10.1186/s12868-015-0149-3